Do you know how diarrhea is common in families? Because it runs in your genes.
Quit making those progeria jokes. They get old very quickly.
What's the difference between acne and a Catholic priest?
Acne doesn't cum on a kid's face 'til they're 13 or 14.
Did you hear about the guy who got hit in the head with a soda can?
He was lucky it was a soft drink!
Why did Susan drop her ice cream? She was hit by a bus.
What's red and bad for your teeth?
A brick.
This person has Down syndrome.
What do you call a retarded fruit?
Mentally in-pear-ed.
If you turn Down syndrome upside down, do they have Up syndrome now?
What's a person with Down syndrome's favorite detergent?
Downy.
What's the chunkiest part of vegetable soup?
The wheelchair.
Do no doctor start with A and A+?
Don't let an extra chromosome get you down.
Don’t have phone sex without protection, you might get hearing aids!
Down syndrome and brownies.
You've got a body inside you--it's called your body bones.
You've got a body inside you. It's called your bones.
You know your doctor is gay when he asks you to touch your toes, and then you feel a rub on your back and a tickle on your anus.
Someone said to me they like greasy food with gravy.
I said no wonder your forehead's so greasy.
My mental health.