What's simultaneously up and down?
A retard on a plane.
What do you call someone with Down Syndrome who smokes weed?
A baked potato.
When the school shooter is just about to leave your classroom, and you think you're in the clear, but the Down syndrome kid says, "Goodbye."
What's the worst part of a Down Syndrome relationship? There's more downs than ups!
What do you call it when a person with Down syndrome gets friendzoned?
Chromozoned.
Don't let an extra chromosome get you down.
What do you call a person with Down syndrome in a bathtub?
Vegetable soup.
Down Syndrome is already a joke.
Unlike my syndrome, I keep my chin up. 🙌🏽😁
Down syndrome kid: Stop being greedy with the Legos! Me: Stop being greedy with the chromosomes!