What do you call it when a person with Down syndrome gets friendzoned?
Chromozoned.
Chromozoned
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Explanation
The joke is a play on words. "Friendzoned" is a term that describes a romantic interest not being reciprocated and becoming a friend. "Chromozoned" combines the word 'chromosome,' which is associated with Down syndrome, with 'zoned' from friendzoned. It's using the similar sound and structure to create a humorous new word.