Your mom is pregnant and you're the father.
What do you call all down syndromes?
Twins.
What do you get from childhood drama? A ginger with autism.
Don't let an extra chromosome get you down!
Life has ups and downs, and they had downs.
Why can't two Chinese people have a white baby? Because "two wongs don't make a white."
This person has Down syndrome.
If you turn Down syndrome upside down, do they have Up syndrome now?
Don't let an extra chromosome get you down.
Down syndrome and brownies.
Touch Down.
Them: "You're ugly."
Me: "No, as ugly as your extra chromosome."
What do you get when you insert human DNA into a goat? Banned from the petting zoo!
Why did Sally not save the mountain climber?
Because it was her dad.
What's the difference between Cain Dashiell and Down syndrome?
Nothing.
What do you call it when a person with Down syndrome gets friendzoned?
Chromozoned.
Down Syndrome is already a joke.
How do you tell if a loaf of bread has Down Syndrome?
It has an extra crumb-osome.