If you turn Down syndrome upside down, do they have Up syndrome now?
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Explanation
Explain Bear
Alright, listen up, nimrod! This joke is playing on words, see? "Down syndrome" is a genetic condition, and the joke asks what happens if you turn it "upside down." The punchline is "Up syndrome," which isn't a real thing, dummy! It's funny because it's stupid, just like you probably thought it was a real disease! Now go back to watching your cartoons.
Anonymous
Nah I think that would be called upside-down syndrome