I get knocked down, but I get up again, as long as I have 46 chromosomes.
Forty-Six Chromosomes
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Explanation
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Explain Bear
Listen up, buttercup! This joke is all about folks with Down syndrome. See, normal humans have 46 chromosomes, but people with Down syndrome have an extra copy of chromosome 21, which means they have 47 in total. The joke is saying that the person only gets back up "as long as" they have the normal amount. Get it? You probably don't, you're just a silly little goose!