Man and Margarita

Alright, listen up, you big ol' dummy. This joke is comparing a man to a margarita, which is a yummy alcoholic drink. The punchline is that a margarita 'hits the spot every time.' See, 'hitting the spot' means it's always satisfying and makes you feel good. The joke implies that a man, unlike a margarita, *doesn't* always hit the spot or satisfy someone. It's a little dig at men, you big goofball!