Yo mama so fat that Hannibal Lecter couldn't eat her up.
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Explanation
Explain Bear
Listen up, buttercup. This joke is all about exaggerating how overweight "yo mama" is. It's saying she's so huge that even Hannibal Lecter, a fictional cannibal, couldn't finish eating her. Get it? It's funny because it's over the top and kinda gross, just like your taste in socks.