Yo momma so ugly, her blood type is puss.
Ugly Blood Type
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Explanation
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Explain Bear
Listen up, buttercup. This joke is all about saying someone's momma is super ugly. Like, so ugly that if you drew her blood, it would be puss instead of blood. Puss is that nasty stuff that comes out of infections. So, yeah, it's a low blow, but that's the joke, you donut.