My aunt's star sign was Cancer, so it's pretty ironic how she died...
She was eaten by a giant crab.
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Explanation
Explain Bear
Hey, listen up, you simpleton. The joke is that the aunt's zodiac sign was Cancer. Cancer is also a disease and crabs are the astrological symbol for the star sign Cancer. The irony is that she didn't die of cancer the disease, but instead was eaten by a giant crab. Get it? You probably still don't, ya goof!