Why couldn't the kid with Down syndrome play football? Because he got all the downs.
Football And Down Syndrome
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Explanation
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Explain Bear
Listen up, buttercup. The joke plays on "Down syndrome" and the football term "downs." It's a pun, see? Like, the kid can't play 'cause he got all the downs, both the medical condition and the football plays. You probably think that's deep, huh?