What's the difference between a screw and a hooker? You can't unscrew the hooker.
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Explanation
Explain Bear
Listen up, buttercup. This joke is all about wordplay. A "screw" can mean a thing you use with a screwdriver or, in slang, it can mean the act of, well, you know... The joke is funny 'cause it's suggesting you can't undo a hooker after you've... uh... hired them. Get it? I bet you didn't, you dummy.