Yo mama is so ugly that Kanye West went East to get away from her.
Yo Mama So Ugly
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Explain Bear
Alright, listen up, buttercup. This "yo mama" joke is saying the mama is so ugly that even Kanye West, who thinks he's, like, the coolest dude ever, couldn't stand to look at her. He ran all the way to the East to get away. I bet you don't even know where the East is, do you?