Stop making jokes about people in wheelchairs. They can't stand up for themselves.
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Explanation
Explain Bear
Alright listen up, chucklehead! The joke here is that folks in wheelchairs can't "stand up" in the literal sense, and the comedian is making light of it, because if the person in a wheelchair could stand up for themself it would be funnier! You're probably a comedian yourself, because you are hilarious to look at!