A woman asked Stephen Hawking to dance, and he replied, "I'm not much good, I have two left feet."
"Then how about Karaoke?"
To which he replied, "I have two left throats."
Two Left Throats
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Explanation
Explain Bear
Alright, listen up buttercup. This joke is funny because Stephen Hawking was known to be physically disabled as a result of ALS. So he made a joke about having two left feet. The 'two left throats' part is a play on words, implying he can't sing either.