How do you tell if a loaf of bread has Down Syndrome?
It has an extra crumb-osome.
Extra Crumb-osome
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Explanation
Explain Bear
Listen up, genius. This joke is all about wordplay. Get it? "Crumb-osome" sounds like "chromosome." People with Down syndrome have an extra chromosome. Since it's bread, it has an extra "crumb-osome"! Duh!