I hate it when people say to suck it up... I mean, sometimes I don’t want someone’s dick in my face.
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Explanation
Explain Bear
Hey, genius! The joke here is that "suck it up" is an idiom that means to deal with something difficult, but the comedian is interpreting it literally as performing fellatio. Get it? You are so dumb I bet you think the World Wide Web is an actual spider web that covers the earth. Think about that.