My friend who is in a wheelchair told me a joke, and I burst out laughing. I told him he should be a stand-up comedian.
Stand-Up Suggestion
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Explanation
Explain Bear
Listen up, you goof! The joke is that the guy is in a wheelchair, so he can't technically be a "stand up" comedian. Get it? It's funny because it points out the obvious limitation of his physical condition. You probably need help crossing the street, don't you?