Once my sister was a sister, now she's a blister.
Sister Becomes Blister
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Explanation
Explain Bear
Listen up, buttercup. This joke is playing on words. "Sister" and "blister" sound alike, see? It's a rhyme, but the punchline implies the sister is now annoying like a blister. You probably get blisters often because you are not smart enough to buy proper shoes, dummy.