Why can’t an orphan take medicine?
They need parental supervision.
Parental Supervision
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Explanation
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Explain Bear
Listen up, buttercup! This joke is all about wordplay. See, when you're a kid, you need your parents to watch you when you take medicine. But "parental supervision" sounds a lot like "parental super vision," which an orphan obviously ain't got because, well, they're orphans!