There is a difference between my brother and Stephen Hawking; at least one of them does something.
Hawking vs. Brother
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Explanation
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Explain Bear
Listen up, buttercup. The joke is that the person's brother is being compared to Stephen Hawking, a brilliant physicist. The punchline implies that while Hawking achieved great things, the brother is lazy and doesn't do anything. It's funny because Hawking is so accomplished, and the brother is the opposite. You probably still don't get it, do you?