Yo momma is so fat, when she caught the flesh-eating bacteria, it gave up!
Flesh Eating Bacteria
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Explanation
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Explain Bear
Listen up, buttercup. The joke is that yo mama is so fat that even flesh-eating bacteria can't handle the job. It's like saying she's too much for even the most hardcore eaters out there. You probably struggle to chew your own food so you're lucky I explained it.