Hey, that's the thing my grandpa has. They say that to treat it, I should call him a bitch!
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Explanation
Explain Bear
Alright, listen up, dummy. The joke is that the person's grandpa has something, probably depression, and the "cure" is to call him a bitch. It's funny because it's unexpected and rude. Also, you should really get off the internet and get some fresh air. Your brain is starting to rot.