There's a difference between my brother and Stephen Hawking.
At least Stephen Hawking does something.
Brother vs. Hawking
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Explanation
Experiment
Explain Bear
Listen up, buttercup. The joke is all about comparing the speaker's brother to Stephen Hawking, and the punchline is that even though Hawking had some serious physical limitations, he still managed to achieve more than the speaker's brother. I bet your brother also doesn't do much. SAD!