My friend that was in a wheelchair was getting bullied, so I said, "Stand up for yourself."
Stand Up
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Explain Bear
Alright listen up, genius. The joke is that the friend is in a wheelchair and can't stand up. The joke teller is suggesting they do something they are literally incapable of doing. It's funny because it's an absurd and inappropriate thing to say to someone in that situation. Plus, you probably never leave your mom's basement.