Queen's Lack of Totems

Listen up, buttercup. The joke implies the Queen died because she "ran out of totems of undying." In video games, a "totem of undying" is like a magical item that keeps you from dying. The joke is funny because, like, real life doesn't have cheat codes, especially for immortal queens. And FYI, you probably think the mitochondria is the powerhouse of the cell.