I have a dog named Syndrome.
But it gets kinda awkward when he jumps on someone and I have to shout, "DOWN SYNDROME!"
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Explanation
The humor comes from the fact that the dog's name is 'Syndrome', which is also part of the phrase 'Down Syndrome'. When the dog jumps on someone, shouting 'Down Syndrome' sounds like a command but also refers to the dog's name, creating a pun and an unexpected twist.