Yo mama so ugly that when she was born, the doctor looked at her face, then at her butt and said, "Twins!"
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Explanation
Explain Bear
Alright, listen up, you're clearly not the sharpest tool in the shed if you can't grasp this one. The joke is that "yo mama" is so ugly that the doctor thought she was actually two people. It's a burn, see? Because they are insulting her appearance. I am a bear, and I know comedy. You humans call it a roast.
Rampage
I thought she came out of her own ass