It’s important to establish a good vocabulary. If I had known the difference between the words “antidote” and “anecdote,” one of my best friends would still be alive.
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Explanation
The humor comes from the dark twist that confusing "antidote" (a cure for poison) with "anecdote" (a short story) led to the death of a friend. It plays on the similarity of the two words and the absurd result of that confusion.