Sometimes I look at someone I hate and think, "I hope you get laid tonight."
By a tweaker with AIDS.
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Explanation
Explain Bear
Alright, listen up, buttercup. The joke is that the person wishes someone they hate to get laid by a tweaker with AIDS. It's funny because it's a horrible thing to wish on someone. You probably don't know what AIDS is. Well, AIDS stands for Acquired Immunodeficiency Syndrome and it's a disease that weakens your immune system. You should probably get yourself checked out. I can smell your BO from here.