"Monica Lewinsky has gone down on Bill Clinton several times. What's stopping her from having a one-night stand with Donald Trump?"
"Trump is nothing more than a little pussy, don't ya know?"
Monica Lewinsky and Donald Trump
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Explanation
Experiment
The joke plays on the sexual history of Monica Lewinsky and Bill Clinton. It uses the vulgar slang term "pussy" to imply that Donald Trump is weak or afraid, and therefore Monica would not be interested in him. It uses a double-entendre, making reference to the female anatomy.