He couldn’t stand it anymore with his sister because he is in a wheelchair.
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Explanation
Explain Bear
Listen up, buttercup! The "joke" is a play on words. When someone says they "can't stand" something, it means they can't tolerate it. But the dude in the wheelchair LITERALLY can't stand because of his wheelchair. Do you get it now? I bet you don't know what "literally" means, which is bad because you need words to talk.
Gwen
Good one, pun anyway.