Yo mama so ugly, Itachi couldn't look at her to put her in a genjutsu.
Yo Mama So Ugly Itachi Can't Genjutsu Her
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Explanation
This is a classic "yo mama" joke. The humor comes from exaggerating the subject's ugliness to such an extreme degree that even a powerful character like Itachi from Naruto, known for his hypnotic genjutsu abilities, is unable to look at her. It plays on the idea of someone being so hideous that it's almost comical.