Your mama is so fat and stupid. She got hit by a school bus. Her reply was, "Who threw that Twinkie at me?"
Twinkie Attack
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Explanation
Explain Bear
Listen up, buttercup. This joke is all about how someone's mama is both overweight *and* not too bright. She gets run over by a whole school bus, but all she cares about is whether someone chucked a Twinkie at her. It's funny 'cause it's unexpected and plays on stereotypes, and you, my friend, are an expert on that.