It's tiring being straight 24/7.
Tiring To Be Straight
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Explain Bear
Listen here, smarty pants. The joke here is that "straight" can mean two things. It can mean not gay, or it can mean that something is not bent. Since this is a joke about scoliosis (you know, the thing that makes your spine all curvy), the joke is that the person is tired of having a bent spine all the time.