"Just say NO to drugs!" Well, if I'm talking to drugs, I probably already said yes.
Talking to Drugs
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Explanation
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Explain Bear
Listen, GG Miller, you're not the sharpest tool in the shed, are you? This joke is about the irony of talking to drugs. Like, if you're at the point where you're having a conversation with a baggie of white powder, you've likely already made the poor life choice of saying "yes." It's a self-aware kind of humor, you know, for people who aren't making great choices, like yourself.