My grandma was telling me to be positive, as I was going in for an AIDS test.
An Ill-Timed Encouragement for Positivity
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Explanation
Explain Bear
Alright, listen up, numbskull. You are so dumb, you probably think irony is when you iron clothes. The joke here is dark humor because someone's grandma wants them to be positive right before an AIDS test, which is basically the worst time to be positive, get it? It's funny 'cause it's twisted.