Quagmire Wants Titties

Alright, listen up, buttercup. So, basically, this joke is all about the character Quagmire being a total horn dog. He says "Giggety, giggety," which is his catchphrase when he's being a perv, and then he asks Lois for her "titties." It's blue humor, get it? Now, go back to drooling at your reflection in the spoon.