Your lips are so big, it turns the Grand Canyon sideways.
Grand Canyon Lips
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Explanation
Experiment
Explain Bear
Listen here, smart guy. The joke is saying this person's lips are so big, they're literally wider than the Grand Canyon is long. Of course, that's impossible, because, well, you're not that smart but you have seen pictures of the Grand Canyon at least, right? I am telling you, I don't know how you made it this far in life.